Cardiovascular Health Clinical Trials

Scientific Background

Cardiovascular health refers to the health of the heart and blood vessels i.e. the cardiovascular system. The American Heart Association (AHA) defines ideal cardiovascular health by the absence of clinically manifest cardiovascular disease (CVD) together with the optimal levels of behavioural (diet quality, physical activity, smoking, body mass index (BMI)) and health (blood cholesterol, blood pressure (BP), blood glucose) metrics referred to as ‘’Life’s Simple 7”.

CVD, which includes coronary heart disease or ischemic heart disease, cerebrovascular disease, peripheral arterial disease, congenital heart disease and deep vein thrombosis (DVT), remains the leading cause of death globally. Cardiometabolic disorders such as hypertension, diabetes, hyperlipidaemia, obesity and metabolic syndrome are common risk factors for CVD. The steady increase of these risk factors and the current global incidence of CVD compels a worldwide search for more effective strategies to prevent and modify the course of CVD.

What Atlantia offer

Atlantia Food Clinical Trials has extensive experience in conducting food clinical trials in the areas of cardiovascular health. Our expert research team will work with sponsor(s) to design and conduct a study most suitable for their investigational product(s), agreeing and applying the most suitable measurements / end-points and statistically powering studies to ensure that study objectives are achieved and reported.

Measurements & Indications

Cardiovascular Health Measurements / End-Points
Indication Measurements / End-Points
Abnormal Body Fat Distribution Body Composition: DEXA; Adipose tissues biomarkers: leptin, adiponectin; Central fat: CT/MRI; Liver fat content: MRS
Atherogenic dyslipidaemia Cholesterol: total, LDL, HDL; Apolipoprotein A1 & B, Omega 3 fatty acids EPA/DHA, conjugated linoleic acid
Vascular Dysregulation Systolic/diastolic blood pressure (BP); Ambulatory BP; Endothelial function: flow mediated dilation (FMD); ACE inhibition
Inflammation High sensitivity C-reactive protein (hsCRP); Cytokines: TNF alpha, interleukin-6; Bradykinin;
Hormonal Factors Leptin, ghrelin, cholecystokinin plasma, glucagon-like peptide (GLP) -1 growth hormones, cortisol
Insulin Resistance Elevated fasting glucose: oral glucose tolerance test (OGTT); postprandial insulin; Elevated free fatty acids; Homeostatic Model Assessment of Insulin Resistance (HOMA-IR)
Thrombosis Fibrinolytic factors (Plasmalogen Activating Inhibitor (PAI) -1); Clotting factors (fibrinogen)

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Check our Resources on Cardiovascular Health