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Immune Health

Scientific Background

The immune system, comprising innate and acquired components, functions to protect the host from infectious agents (bacteria, viruses, fungi, parasites) and transformed cells. Dysregulation of the immune system underlies many human diseases, including diabetes, autoimmunity, allergy and cancer and therefore a “healthy” immune function is critical to overall human health.

The function of the immune system is influenced by genetics, age, gender, lifestyle (diet, exercise, smoking), stress, hormonal status, history of infections and vaccinations, and early life experiences and thus there are large inter-individual variations in immune functions, even among the healthy. To investigate immune health, it is therefore essential to consider the different components of the immune system when designing, assessing and interpreting human studies.

What Atlantia offer

At Atlantia Food Clinical Trials our expert research team will work with sponsor(s) to design and conduct a study most suitable for their investigational product(s), agreeing and applying the most suitable measurements / end-points and statistically powering studies to ensure that study objectives are achieved and reported.

Measurements & Indications

Techniques End-Points
Flow Cytometry Next Generation Sequencing Cytokines: Interferons (IFN) e.g. IFN-g, Interleukins (IL) e.g. IL-1B, IL-6, IL-10, Tumour Necrosis Factors (TNF) Granulocytes: Neutrophils, Basophils, Eosinophils
PCR Multiplexed Immunoassay Glucocorticoid: cortisol Immunoglobulins (Ig) e.g. IgA, IgE Lymphocytes; T, B and Natural Killer (NK) cells, helper T cells, cytotoxic T cells
ELISA Single Cell Analysis e.g. Proteomics high-sensitivity C-reactive protein (hsCRP) Monocytes / Macrophages

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Check our Resources on Immune Health