Immune Health Clinical Trials
Scientific Background
The immune system, comprising innate and acquired components, functions to protect the host from infectious agents (bacteria, viruses, fungi, parasites) and transformed cells. Dysregulation of the immune system underlies many human diseases, including diabetes, autoimmunity, allergy and cancer and therefore a “healthy” immune function is critical to overall human health.
The function of the immune system is influenced by genetics, age, gender, lifestyle (diet, exercise, smoking), stress, hormonal status, history of infections and vaccinations, and early life experiences and thus there are large inter-individual variations in immune functions, even among the healthy. To investigate immune health, it is therefore essential to consider the different components of the immune system when designing, assessing and interpreting human studies.
What Atlantia offer
Atlantia Food Clinical Trials has extensive experience in conducting human dietary intervention studies in the area of immunity and infection in various target populations including children, the elderly, and other immunocompromised populations.
We have conducted trials on a variety of investigational food products (IP), ranging from probiotics, prebiotics, fibers and a range of other substrates, including botanical extracts, minerals, vitamins and peptides.
We have a large database of healthy subjects striated across gender and age, and also a considerable patient database.
Our expert research team will work with sponsor(s) to design and conduct a study most suitable for their IP, agreeing and applying the most suitable diagnostics. We can statistically power your study to ensure that your objectives are achieved and reported in accordance with EFSA and FDA guidelines.
Measurements & Indications
| Techniques | End-Points | ||
| Flow Cytometry | Next Generation Sequencing | Cytokines: Interferons (IFN) e.g. IFN-g, Interleukins (IL) e.g. IL-1B, IL-6, IL-10, Tumour Necrosis Factors (TNF) | Granulocytes: Neutrophils, Basophils, Eosinophils |
| PCR | Multiplexed Immunoassay | Glucocorticoid: cortisol Immunoglobulins (Ig) e.g. IgA, IgE | Lymphocytes; T, B and Natural Killer (NK) cells, helper T cells, cytotoxic T cells |
| ELISA | Single Cell Analysis e.g. Proteomics | high-sensitivity C-reactive protein (hsCRP) | Monocytes / Macrophages |
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