Skin Health Clinical Trials | Atlantia Food Clinical Trials

Skin Health Clinical Trials

Scientific Background

The human skin is the largest organ of the body with functions that include sensation, temperature regulation, water conservation, vitamin D synthesis and immunological surveillance. It is also the single most important determinant of human appearance, genetic heritage and identity. It is not surprising, therefore, that any impairment or disease of the skin has a profound impact on the general health, well-being and self-respect of an individual.

Skin diseases remain a major cause of disability worldwide; in 2013 they were responsible for 41.6 million Disability Adjusted Life Years (DALYs) globally (as a reference point, the leading cause of global DALYs over the past decade has been ischemic heart disease, responsible for 150.2 million DALYs in 2013). Diseases of the skin may be infectious, congenital, degenerative, inflammatory or cancerous and affect all ages from cradle to grave. Some of the more frequent conditions affecting the skin include atopic dermatitis predominantly affecting children, acne vulgaris posing a massive burden to teenagers, psoriasis and rosacea primality affecting the adult population and ulceration and pruritis representing debilitating conditions in the aging population.

Factors that affect the health of skin include age, genetics, environment (photodamage, air pollution) and lifestyle (smoking, stress, alcohol and nutrition). In addition, the skin’s microbiome is extremely important; the “mutualistically symbiotic” microbes that make up part of the skin barrier, together with a person’s innate immunity, combine to form a delicate balance needed to maintain healthy skin. If this balance is disturbed, the host becomes more susceptible to inflammatory diseases and cutaneous infections. It is suggested that microbiota diversity alone can predict whether skin is healthy or not.

What Atlantia offer

As a spin out of the APC Microbiome Ireland, Atlantia Food Clinical Trials has extensive experience in conducting clinical trials in skin health and the skin microbiome. Assesments include Transepidermal Water Loss (TEWL), hydration and wrinkles.

We have conducted a large number of trials on a variety of investigational products including cosmoceuticals, nutricosmetics, probiotics, prebiotics, oils and fatty acids.

We have a large database of healthy subjects striated across gender and age, and also a considerable patient database.

Our expert research team will work with sponsor(s) to design and conduct a study most suitable for their IP, agreeing and applying the most suitable diagnostics. We can statistically power your study to ensure that your objectives are achieved and reported in accordance with EFSA  and FDA guidelines.

Measurements & Indications

Skin Health Assessment (SUBJECTIVE)
Overall Dry Skin (Xerosis) Score (ODS): 5 point clinical assessment of skin dryness
5-Dimension (Degree, Duration, Direction, Disability & Distribution) Itch Scale: measure of pruritis
WHO-Five Well-being Index (WHO-5): self-reported measure of current mental wellbeing
Skin Tear Audit Research (STAR) classification system: clinical assessment of presence of skin tears
Richards-Campbell Sleep Questionnaire (RCSQ): self-assessment of sleep quality
Dietary Analysis: FFQ, 3 day diary
Skin Health Assessment (OBJECTIVE)
Epidermal Hydration: Cornometer; Skin surface pH: Skin pH Meter; Transepidermal Water Loss (TEWL): Tewameter; Erytherma & Melanin: Mexameter; Skin topography (wrinkle area & depth): Visiometer: Skin firmness/elasticity: Cutometer; Minimal Erytherma Dose (MED):Durham Erytherma Tester
Profiling of skin microbiota: Sequencing, Transcriptomics, Functional Genomics, Flow Cytometry, PCR
Profiling of skin lipids: Lipidomics


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Check our Resources on Skin Health