Nutritional Health

Nutritional Health

Nutritional Health

Delivering human dietary intervention studies to companies globally

Atlantia Food Clinical Trials has considerable experience in providing human clinical intervention studies to investigate the uptake of specific nutritional components, such as uptake of different forms of dietary protein or iron. We have carried out trials looking at different forms of protein, such as whey, casein, caeseinate, and micellar forms of protein for different applications, such as sports nutrition, sarcopenia in the elderly, and post-prandial acute studies. We also have experience in investigating the acute uptake/bioavailability of different formulations of iron.

We work with our clients to design a study most suitable for their products in accordance with EFSA guidelines, analysing peer reviewed publications, agreeing the most suitable end-points and statistically powering studies to ensure that studies will meet requirements. We have an extensive database of suitable volunteers, such as healthy, athletes, and elderly, as well as groups with mild illnesses in order to support volunteer recruitment for any trial type. The types of measurements available include;

Nutrient studies

  • Blood plasma testing for both essential and non-essential amino acids and metabolites: - Essential - histidine, isoleucine, leucine,methionine, phenylalanine, threonine, valin - Non-Essential-alanine, arginine, asparagine, cysteine, cysteic acid, glutamine, proline, serine, tyrosine.
  • Plasma ketones and creatinine, urinary nitrogen.
  • Plasma glucose, insulin, serum creatinine, serum triglycerides, serum and urinary urea, urinary ammonia, serum and urinary protein levels.
  • Lipid analysis (triglycerides etc.)

Body composition measurements

  • Body composition measurements e.g. lean muscle, % body fat etc. using DXA or bio impedance.
  • We also have access to MRI and CT scans.

Sports performance

  • Physical performance – time per distance, acceleration, aerobic capacity/VO2, flexibility, strength and 1REP Max
  • Endurance – e.g. lactate threshold, multi-sprint endurance
  • Muscle mass/ strength.

Cardiovascular / Metabolic Health

  • Blood pressure, flow mediated dilation (FMD)
  • Low grade chronic inflammation e.g. inflammatory markers e.g. IL6, CRP.
  • Cardiovascular – ambulatory blood pressure, vascular function (FMD), blood lipids etc.

Protein expertise

  • Access to a large protein lab – amino acid composition, HPLC, nano LC and MS, with experience in developing protein hydrolysates, and simulated gastric digestion/protein stability.